Research

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  1. Sfera A, Hazan S, Klein C, Zapata-Martin del Campo CM, Sasannia S, Anton JJ, Rahman L, Andronescu CV, Sfera DO, Kozakidis Z, Nicolson GL. Microbial translocation disorders: assigning an etiology to idiopathic illnesses. Applied Microbiology 2023; 3(1): 212-240
  2. Nicolson, GL. Membrane Lipid Replacement—a functional approach to repairing cellular membranes, reducing symptoms, and restoring function.
    Functional Food Science 2022; 2(8): 198-204
    (Click to read)
  3. Enhancement of Nutrient Bioavailability and Reductions in Symptom Severities in Chemically Exposed Veterans Townsend Letter 2022
  4. Nicolson GL, Settineri, R, Breeding PC. Recent Research on Membrane Lipid Replacement with NTFactor Lipids®: Enhancement of Nutrient Bioavailability and Reductions in Symptom Severities in Chemically Exposed Veterans Townsend Letter 2022
    (Click to read)
  5. Ash, M.E.; Settineri, R; Nicolson GL. Fatigue, Immunity and Inflammation: Their Resolution Using Natural Medicine. Townsend  E Letter; June 4, 2022
    https://www.townsendletter.com/article/352-fatigue-immunity-inflammation-natural-resolution/
  6. Nicolson GL, Breeding PC. Membrane Lipid Replacement with glycerolphospholipids slowly reduces self-reported symptom severities in chemically exposed Gulf War veterans. International Journal of Translational Medicine 2022; 2(2):    
    (Click to read)
  7. Settineri R, Ji J, Shields ZP, Shirvani T, McLaren CE, Nicolson GL. The effects of Membrane Lipid Replacement with NTFactor® Lipids on increasing the bioavailability of three test nutrients. Bioactive Compounds in Health & Disease 2022, 5(5): 106-116.
    (Click to read)
  8. Nicolson, G.L.; Ferreira deMattos, G.; Ash, M.; Settineri, R.; Escribá, P.V. Fundamentals of Membrane Lipid Replacement: A Natural Medicine Approach to Repairing Cellular Membranes and Reducing Fatigue, Pain, and Other Symptoms While Restoring Function in Chronic Illnesses and Aging. Membranes 2021, 11, 944.
    (Click to read)
    (Special Issue on Advances in Membrane Lipid Replacement and Therapy)
  9. Medica, A, Aitken,R, Nicolson, GL, Sheridan, AR, Swegen,A, De Luliis,G, Gibb,Z.Ferreira de Mattos G, Ash, ME, Settineri R. , Escriba, P. Glycerophospholipids protect stallion spermatozoa from oxidative damage in vitro. Reproductive and Fertility (2021) 2 199-209.
    (Click to read)
  10. Nicolson GL, Breeding PC. Membrane Lipid Replacement with NTFactor Lipids® reduces pain, fatigue, gastrointestinal and other symptoms in patients with peripheral pain. Townsend Letter2020; 449: 17-20.
    https://www.townsendletter.com/article/449-membrane-lipid-replacement-ntfactor/
  11. Nicolson GL, Settineri R. No Evidence of allergenic reactions to soy lecithin phospholipids used in Membrane Lipid Replacement Studies.  Bioactive Compounds in Health and Disease 2021; 4(1): 9 – 13
    (Click to read)
  12. Nicolson GL, Breeding PC. Settineri R, Ferreira de Mattos G. Aging and chronic illnesses: Membrane Lipid Replacement for restoring mitochondrial function and reducing fatigue, pain, and other symptoms in aged individuals. Bioactive Comp. Health Dis. 2020; 3(10): 194-203.
    (Click to read)
  13. Nicolson GL, Breeding P. Membrane Lipid Replacement: reduction of pain, fatigue, gastrointestinal and other symptoms in patients with peripheral pain: case reports. Journal of  Healthcare & Prevention 2020; 3(2): 1-4.
    (Click to read)
  14. Nicolson, G.L. and Breeding, P. Membrane Lipid Replacement with NT Factor Lipids and reducing fatigue, gastrointestinal and other symptoms in patients with peripheral pain: case reports.  Case Reports and Reviews, 2020
    (Click to read)
  15. Nicolson GL, Ferriera de Mattos G. COVID-19 Coronavirus: Is infection along with Mycoplasma or other bacteria linked to progression to a lethal outcome? International Journal of  Clinical Medicine 2020; 11: 282-302.
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  16. Nicolson GL. Pathogenic mycoplasma infections in chronic illnesses: general considerations inselecting conventional and integrative treatments. International Journal of Clinical Medicine2019; 10: 477-522.
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  17. Gonzalez MJ, Seyfried T, Nicolson GL, Barclay BJ, Matta J, Vasquez A, Agostino DD, Olalde J, Duconge J, Hunninghake R, Berdiel MJ, Cintron A. Mitochondrial correction: a new therapeutic paradigm for cancer and degenerative diseases. Journal of Orthomolecular Medicine 2018; 33(4): 1-20.
    (Click to read)
  18. Nicolson, G.L., Settineri, R., Ferreira, G. and Breeding, P. Reduction of pain, fatigue, gastrointestinal and other symptoms and improvement in quality of life indicators in fibromyalgia patients with Membrane Lipid Replacement glycerolphospholipids and controlled-release caffeine. Intern. J. Clin. Med. 2018; 9: 560-579.
    (Click to read)
  19. Ferreira, G. Costa, C., Bassaizteguy, V., Santos, M., Cardozo, R, Montes, J, Settineri, R. and Nicolson, G.L. Membrane Lipid Replacement promoted by Incubation of mature human spermatozoa with glycerolphospholipid mixtures increases their motility and resistance to oxidative damage, PlosOne(2018)
    (Click to read)
  20. Nicolson, G.L., Ferreira, G., Settineri, R., Ellithorpe, R.R., Breeding, P. and Ash, M.E. Mitochondrial dysfunction and chronic disease: treatment with Membrane Lipid Replacement and other natural supplements. MITOCHONDRIAL BIOLOGY AND EXPERIMENTAL THERAPEUTICS, Edited by Dr. Paulo J. Oliveira, Chapter 22, Springer Press, NY, 2018.
    (Click to read)
  21. Hiroshi, A., Terauchi, M., Osaka, Y., Akiyoshi, M., Kato, and Miyasaka, N. Effect of soy lecithin on fatigue and menopausal symptoms in middle-aged woman: a randomized, double-blind, placebo-controlled study. Nutrition Journal (2018) 17:4.  00
    (Click to read)
  22. Nicolson, G.L., and Ash, ME. Membrane Lipid Replacement for chronic illnesses, aging and cancer using oral glycerolphospholipid formulations with fructooligosaccharides to restore phospholipid function in cellular membranes, organelles, cells and tissues. Biochim. Biophys. Acta 2017; 1859: 1704-1724.
    (Click to read)
  23. Nicolson, G.L., Rosenblatt, S., Ferrira de Mattos, G., Breeding, P.C., Ellithorpe, R.R. and Ash, ME. Clinical use of Membrane Lipid Replacement supplements in restoring membrane function and reducing fatigue in chronic diseases and cancer. Discoveries 4(1):e54 (2016) DOI: 10.15190/d.2016.1 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941554   OR  http://www.immed.org/treatmentconsiderations/06.11.2016.update/Clinical_Uses_MLRNicolsonDiscoveries2016. OR (Click to read)
  24. Nicolson, G.L. Membrane Lipid Replacement: clinical studies using a natural medicine approach to restoring membrane function and improving health. Intern. Clin. Med. 7:133-143(2016).
    (Click to read)
  25. Ellithorpe, R.R, Settineri R., Ellithorpe, T. and Nicolson, G.L. Blood homocysteine and fasting insulin levels are reduced and erythrocyte sedimentation rates are increased with a glycophospholipid-vitamin formulation: a retrospective study in older subjects. Funct. Food Health Dis. 5(4): 126-135 (2015).
    (Click to read)
  26. Nicolson, G.L., Mitochondrial dysfunction and chronic disease: treatment with natural supplements. Integr. Med. 13(4): 35-43 (2014)
    (Click to read)
  27. Nicolson, G.L., Settineri, R. and Ellithorpe, R. Neurodegenerative and fatiguing Illnesses, infections and mitochondrial dysfunction: use of natural supplements to improve mitochondrial function. Funct. Foods Health Dis. 4(1): 23-65 (2014).
    (Click to read)
  28. Nicolson, G.L. and Ash, M.E. Lipid Replacement Therapy: a natural medicine approach to replacing damaged phospholipids in cellular membranes and organelles and restoring function. Biochim. Biophys. Acta 1838: 1657-1679 (2014).
    (Click to read)
  29. Nicolson, G.L. Mitochondrial dysfunction and chronic disease: treatment with natural supplements. Alt. Ther. Health Med. 20(Suppl. 1): 18-25 (2014).
    (Click to read)
  30. Ash, M., Settineri R. and Nicolson, G.L. Fatigue, Immunity and Inflammation: their resolution using natural medicine. Townsend Lett. 352(10): 48-51 (2012).
    http://www.townsendletter.com/Nov2012/fatigue1112.html
  31. Nicolson, G.L. Mitochondrial dysfunction and disease: loss of mitochondrial function in chronic diseases and its reversal with Lipid Replacement Therapy. Public Health Alert (10): 1-4 (2012).
    (Click to read)
  32. Nicolson, G.L., Settineri, R. and Ellithorpe, R. Lipid Replacement Therapy with a Glycophospholipid Formulation, NADH and CoQ10 Significantly Reduces Fatigue and Improves Mood and Cognition in Intractable Fatiguing Illnesses and Chronic Lyme Disease. Townsend Lett. 347(6): 58-61 (2012). http://www.townsendletter.com/June2012/June2012.html
  33. Nicolson, G.L., Settineri, R. and Ellithorpe, R. R. Glycophospholipid formulation with NADH and CoQ10 significantly reduces intractable fatigue in Western blot-positive chronic Lyme disease patients: preliminary report. Funct. Food Health Dis. 2(3): 35-47 (2012).
    (Click to read)
  34. Nicolson, G.L., Settineri, R. and Ellithorpe, R. R. Lipid Replacement Therapy with a glycophospholipid formulation with NADH and CoQ10 significantly reduces fatigue in intractable chronic fatiguing illnesses and chronic Lyme disease. Intern. J. Clin. Med. 3(3): 163-170 (2012).
    (Click to read)
  35. Ellithorpe, R.R., Settineri, R., Jacques, B. and Nicolson, G.L. Lipid Replacement Therapy functional food with NT Factor for reducing weight, girth, body mass, appetite, cravings for foods and fatigue while improving blood lipid profiles. Funct. Food Health Dis. 2(1): 11-24 (2012).
    (Click to read)
  36. Ellithorpe, R.R., Settineri, R., Mitchell, C.A., Jacques, B., Ellithorpe, T. and Nicolson, G.L. Lipid replacement therapy drink containing a glycophospholipid formulation rapidly and significantly reduces fatigue while improving energy and mental clarity. Funct. Food Health Dis. 1(8): 245-254 (2011).
    (Click to read)
  37. Nicolson, G.L. Nutritional supplements for cancer-associated fatigue and cancer therapy—A molecular basis for restoring mitochondrial function. In Topics in Cancer Survivorship, vol. 2, ISBN 978-953-307-894-6, InTech, Rijeka, 147-164 (2011).
    (Click to read)
  38. Nicolson, G.L. and Settineri, R. Lipid Replacement Therapy: a functional food approach with new formulations for reducing cellular oxidative damage, cancer-associated fatigue and the adverse effects of cancer therapy. Funct. Food Health Dis. 1(4): 135-160 (2011).
    (Click to read)
  39. Nicolson, G.L. An answer to the most common medical complaint—Fatigue. Explore 19: 1-4 (2010).
    (Click to read)
  40. Nicolson, G.L., Ellithorpe, R.R., Ayson-Mitchell, C., Jacques, B., and Settineri, R. Lipid Replacement Therapy with a glycophospholipid-antioxidant-vitamin formulation significantly reduces fatigue within one week. J. Am. Nutraceutical Assoc. 13(1): 10-14 (2010).
    (Click to read)
  41. Nicolson, G.L. Lipid replacement therapy: a nutraceutical approach for reducing cancer associated fatigue and the adverse effects of cancer therapy while restoring mitochondrial function. Cancer Metastasis Rev. 29(3): 543-552 (2010).
    (Click to read)
  42. Nicolson, G.L. Finally an answer to the most common medical complaint—Fatigue. Public Health Alert (10): 1-5 (2011).
    (Click to read)
  43. Nicolson, G.L., Ellithorpe, R., and Settineri, R. Dietary supplement Healthy Curb for reducing weight, girth, body mass, appetite and fatigue while improving blood lipid values with NT Factor Lipid Replacement Therapy. J. Invest Myalgic Encephalomyelitis 3(1): 39-48 (2009).
    (Click to read)
  44. Nicolson, G.L. and Conklin, K.A. Reversing mitochondrial dysfunction, fatigue and the adverse effects of chemotherapy of metastatic disease by Molecular Replacement Therapy. Clin. Exp. Metastasis 25: 161-169 (2008).
    (Click to read)
  45. Conklin, K.A. and Nicolson, G.L. Molecular replacement in cancer therapy: reversing cancer metabolic and mitochondrial dysfunction, fatigue and the adverse effects of therapy. Curr. Cancer Therapy Rev. 4: 66-76 (2008).
    (Click to read)
  46. Nicolson, G.L. Lipid replacement and antioxidant supplements to prevent membrane oxidation and restore mitochondrial function in metabolic syndrome and fatiguing illnesses. Townsend Lett. 286: 112-120 (2007).
    http://www.townsendletter.com/May2007/lipidreplace0507_0709.html
  47. Nicolson, G.L. Metabolic syndrome and mitochondrial function: molecular replacement and antioxidant supplements to prevent membrane oxidation and restore mitochondrial function. J. Cell. Biochem. 100: 1352-1369 (2007).
    (Click to read)
  48. Nicolson, G.L. and Conklin, K.A. Molecular replacement for cancer metabolic and mitochondrial dysfunction, fatigue and the adverse effects of cancer therapy. Cancer Genomics Proteomics 3: 159-168 (2006).
    (Click to read)
  49. Nicolson, G.L. and Ellithorpe, R. Lipid replacement and antioxidant nutritional therapy for restoring mitochondrial function and reducing fatigue in chronic fatigue syndrome and other fatiguing illnesses. Chronic Fatigue Syndr. 13(1): 57-68 (2006).
    (Click to read)
  50. Nicolson, G.L. Lipid Replacement/Antioxidant Therapy as an adjunct supplement to reduce the adverse effects of cancer therapy and restore mitochondrial function. Pathol. Oncol. Res. 11: 139-144 (2005).
    (Click to read)
  51. Nicolson, G.L. Lipid replacement/antioxidant therapy for anti-aging, fatigue and restoration of mitochondrial function. AgroFood High Tech 16(3): 20-23 (2004)
    (Click to read)
  52. Nicolson, G.L. Lipid replacement as an adjunct therapy in chronic fatigue, anti-aging and restoration of mitochondrial function. J. Am. Nutraceut. Assoc. 6(3): 22-28 (2003).
    (Click to read)
  53. Agadjanyan, M., Vasilevko, V., Ghochikyan, A., Berns, P., Kesslak, P., Settineri, R.A. and Nicolson, G.L. Nutritional supplement (NT Factor) restores mitochondrial function and reduces moderately severe fatigue in aged subjects. J. Chronic Fatigue Syndr. 11(3): 23-36 (2003).
    (Click to read)
  54. Ellithorpe, R.R., Settineri, R. and Nicolson, G.L. Reduction of fatigue by use of a dietary supplement containing glycophospholipids. Am. Nutraceut. Assoc. 6(1): 23-28 (2003).
    (Click to read)
  55. Nicolson, G.L. Chronic fatigue, aging, mitochondrial function and nutritional supplements. Townsend Letter Doctors 240(7): 72-76 (2003).
    (Click to read)
  56. Seidman, MD. NT Factor® Spares the Age Related loss of Nerve Function, Energy and Genetic damage in animals. (2002). Otolaryngology- Head and Neck Surgery, 127, pp.138-143.
    (Click to read)
  57. Seidman, MD. (2001). Polyunsaturated Phosphatidylcholine in NT Factor Improves Mitochondrial Function, Auditory Sensitivity and May Slow Some Aspects of the Aging Processes. Anti-Aging Medical News, Winter 2001.
    (Click to read)
  58. Nicolson, G.L. Lipid Replacement as an Adjunct to Therapy for Chronic Fatigue, Anti-Aging and Restoration of Mitochondrial Function. J. Am. Nutraceutical Assoc. 4(1):11-19 (2001).
    (Click to read)
  59. Colodny, L. (2000). Integration of Traditional and Complementary Medicine During Chemotherapy, A Physician’s Viewpoint: Interview with Rudy A. Segna, MD, FACOG. Journal of the American Nutraceutical Association, 3(3), pp.51-53.
    (Click to read)
  60. Cancer Patients had an improved Quality of Life when Taking NT Factor® with a multi-vitamin complex. (2000). Journal of the American Nutraceutical Association, 3(2), pp.17-25.
    (Click to read)
  61. Block, J. and Evans, S. (2000). . A Review of recent Results Addressing the Potential Benefits of Antioxidants with cancer Drug Therapy. Journal of the American Nutraceutical Association, 4(1), pp.11-19.
    (Click to read)
  62. Block, J. and Evans, S. (2000). Newburg, D. (1999). The Beneficial Effects of Phosphoglycolipid Extract, NT Factor, on Normal and Cancerous Cells. Proprietary Report. Journal of the American Nutraceutical Association, 3(3), pp.6-16.
    (Click to read)
  63. Blaylock, R. (2000). A Review of Conventional Cancer Prevention and Treatment and the Benefits of Adding Nutraceutical Supplements and Antioxidants to Treatment. Journal of American Nutraceutical Association. 3(3), Fall 2000.
    (Click to read)
  64. Newburg, D. (1999). The Beneficial Effects of Phosphoglycolipid Extract, NT Factor, on Normal and Cancerous Cells. Proprietary Report.
    (Click to read)