About NTFactor® / NTFactor® Lipids
NTFactor® (NTF) is a plant food-derived phospholipid complex providing a patented lipid complex, prebiotics and probiotics designed to support healthy cell membranes — especially the membranes of mitochondria, where cellular energy is produced.
Patented NTFactor® Lipids (NTFL) (US PAT No. 8,877,239) are the active membrane phospholipids within NTFactor®. They include a broad spectrum of naturally occurring phosphoglycolipids that help restore and maintain membrane integrity.
Membrane Lipid Replacement (MLR) is a nutritional approach that supplies undamaged phospholipids to help replace oxidized membrane lipids and support healthy membrane structure and function. It is the scientific name used to identify NTFactor® products in medical journals that do not allow brand names.
NTFactor® is a dietary supplement ingredient. It supports normal cellular function but is not intended to diagnose, treat, cure, or prevent disease.
Energy production requires an intact membrane gradient. Supporting membrane structure helps maintain that gradient, allowing mitochondria to function efficiently.
Human studies using NTF® and NTFL-containing products suggest that improvements in fatigue and cellular function can be observed within days to several weeks, with continued progressive benefit over longer and regular use.
Yes. NTFactor® has been evaluated in multiple human clinical studies examining fatigue, cognition, quality of life, and mitochondrial function markers. These studies have been consistently positive across numerous challenges and have used different nutritional blends, such as Propax with NTFactor® and Healthy Aging with NTFactor®. Over 75 scientific publications relate to the broader Membrane Lipid Replacement research program while using and reporting on NTFactor®-containing products, including human and mechanistic studies. These studies can be found on commonly used databases such as pubmed.com or at ntfactor.com/research.
All of the many published studies using NTF products have appeared in peer-reviewed journals, and the research spans both human and animal models.
MLR research indicates that supplying unoxidized phospholipids helps dilute and replace damaged membrane lipids, supporting healthier membrane composition. This is accomplished simultaneously with normalizing Mitochondrial Membrane Potential.
Healthy mitochondrial function supports normal brain energy metabolism. Multiple clinical studies have reported substantial improvements in fatigue-related cognitive measures.
Aging is associated with cumulative membrane oxidation. Supporting membrane renewal may help maintain cellular function over time.
Benefits & Outcomes
Clinical studies have shown substantial reductions in fatigue scores in individuals supplementing with NTFactor® containing products.
Participants in fatigue-related studies have reported improvements in concentration and cognitive performance measures.
By supporting mitochondrial membrane integrity, NTFL helps maintain normal cellular energy production as part of healthy aging.
Most individuals report improvements within days and substantial benefits in 4–8 weeks, though responses vary.
Studies suggest sustained improvements during continued use; long-term maintenance is best supported with consistent supplementation. While that is true, NTFL has shown great durability in clinical trials. Durability is the ability to maintain benefits after ending supplementation. For example, in one trial after a washout, (meaning stopping treatment for the purpose of measuring durability), the population being tested for 12 weeks still had the benefit seen at the 30-day measuring point during the trial, ~30%.
Safety & Use
NTFactor® and NTFL are composed only of plant-derived phospholipids and other food-derived ingredients and have been used safely in long-term supplementation studies.
NTFactor® is generally well tolerated. Mild digestive adjustment may occur in sensitive individuals.
Yes. NTFL supports membrane structure, while nutrients like CoQ10 or NAD precursors support biochemical pathways. They may be complementary. Both CoQ10 and NAD precursors require mitochondrial membrane potential (ΔΨm) to work, as do all mitochondrial functions. In fact, NTFL has been shown to improve the utilization of CoQ10 by more than 200%.
Individuals with specific medical conditions or who are pregnant, nursing, or taking medications should consult a healthcare professional before use.
Differentiation
Many mitochondrial supplements supply metabolic cofactors. NTFL focuses on supporting the membrane structure that allows those pathways to function efficiently — addressing the physical platform of energy production.
Yes. NTFactor® Lipids are protected by U.S. Patent No. 8,877,239 B2, titled Compositions and Methods for Membrane Lipid Replacement. The patent covers compositions of protected phospholipids and their use in supporting cellular membrane integrity and mitochondrial function as part of Membrane Lipid Replacement (MLR).
Yes. NTFactor® (which contains NTFactor® Lipids along with prebiotics and probiotics) is commonly used in tablets and capsules. The active ingredient, NTFactor® Lipids (NTFL), can also be incorporated into powders, beverages, and other nutritional formulations designed to support cellular energy and membrane health.
Yes. Both NTFactor® (NTF) and NTFactor® Lipids (NTFL) are produced using stabilization techniques that help protect phospholipids from oxidation, including during digestion. This allows them to remain stable in a variety of delivery formats including tablets, capsules, wafers, and other functional nutrition formats.
NTFactor® Lipids are manufactured using only Non-GMO food-grade phospholipids according to recognized Good Manufacturing Practices to assure adherence to our strict quality and purity standards.
Yes. Healthcare professionals and interested readers can access summaries of published studies and supporting scientific background on Membrane Lipid Replacement and NTFactor® Lipids at www.ntfactor.com/research, where a linked bibliography to most publications, including original research, is available. They are also available in the traditional manner, using public and private databases, such as www.pubmed.org. We strive to use open access venues as often as possible.
Orders and Shipping
We require international customers to contact us directly so we can explain our policy for international shipments. International shipments may incur an additional postage charge that will be determined at the time of shipping. We do not guarantee delivery of packages overseas. This is due to the various customs policies for each country. As customs can on occasion seize a package, it may be lost in the system and we will be unable to confirm delivery did not occur. We ship all international packages USPS for better possibility of arrival. If you still wish to order, please contact us by phone at 1-631-543-2780 between 9AM-5PM Eastern Time.
For certain products you’ll notice a Subscribe & Save option while placing your order. Choosing this option enables you to save up to 20% off the single purchase price while ensuring that you’ll never run out. You get to choose the amount of product and you want based on the frequency you select.
You will have complete control over your Subscribe & Save options through your My Account settings, or by contacting us by telephone (800-982-9158) or email (TalkToNTI@ntfactor.com). You’ll be able to skip an upcoming delivery, change your delivery frequency, method of payment and other options, or cancel your subscription at any time.
Standard Shipping on all orders under $75 is determined at the time you order based on location and current rates. For all orders over $75 Standard Shipping is free! Standard shipping delivers in 5-7 days. Orders placed before 1pm Monday thru Friday will ship on the same day. All others will ship on the next business day. On all orders you will be given the choice of expediting your delivery for an additional shipping charge.
Yes, there is a 45-day money back guarantee. Simply contact us by phone at 1-800-982-9158 between 9AM-5PM Eastern Standard Time.
