What’s The Bottom Line on Joint Pain?

60-70% of people over the age of 70 have some degree of Osteoarthritis (OA).  So learning what starts the process and the inflammation that comes with it are important.

The bottom line may be your cells; in particular, your mitochondria.  So what are these little things, and how do they relate to you.  The mitochondria regulate the cells very survival, and the way it functions.  But more specifically how does that affect such an important age related disease as arthritis?  Is there a way to deal with this?

Mitochondrial mutations, and oxidative stress (free radical damage), are commonly the cause of age related diseases.  Among those diseases, is osteoarthritis, a related rheumatic disease, most commonly seen in the degradation and loss of joint cartilage.  The death of joint cells is a prominent feature of the process of decline.  As these cells are damaged they can’t replace your joint cartilage at the rate it used to. That leads to loss of cartilage.  It also leads to inflammation, the basis for most OA pain flare ups.

The danger to all mitochondria is nitric oxide (NO).  It is this that causes the damage the synovial fluid in your joints and the joints cells.  The higher the amount of NO is the greater the cell damage, and death.

Now several studies are pointing out this important role mitochondria play in both OA and Rheumatoid Arthritis.  They point to the idea that it is this dysregulation in cartilage cells that may be the most basic root of the overall problem.

From the beginning to the end your cells are the key to your good health.

 

References:

Journal of American College of Rheumatology, 2008 58:8 2217-18

Mitochonrion 2004 Sept4: (5-6): 715-28

BMC Musculselet Disord. 2011 Feb 8;12-42

Mol Cell Proemics, 2009 Jan;8(1); 172-89