What is fatigue and how is it treated?

Most of us are familiar with fatigue. It’s when you’re so tired you can’t perform even simple tasks. Chronic fatigue is when you feel fatigued almost all of the time.

We posed a number of questions to Garth L. Nicolson, Ph.D., Nobel-Prize nominated scientist, and President and Chief Scientific Officer of The Institute for Molecular Medicine about this important issue.

Professor Nicolson, Why do people get chronic fatigue?

Chronic fatigue or fatigue that lingers and is not reversed by normal sleep occurs naturally during aging and in most degenerative diseases, including neurological, respiratory, coronary, musculoskeletal, metabolic and gastrointestinal diseases, infections and cancer.

Should we be concerned about fatigue, even if it’s a natural process of aging?

Absolutely. Chronic or intractable fatigue is the most common complaint of patients seeking medical care. It is also an important secondary condition in many degenerative diseases. If we are chronically fatigued, it is a sign at a cellular level that there may be significant damage to the mitochondria , which are the energy sources that are like little batteries inside our cells that provide cells with high energy molecules.

Why is that important?

Damage to mitochondrial components, especially mitochondrial membranes, which occurs mainly by oxidation, can result in increased ion leakage across mitochondrial membranes, and this can impair the ability of mitochondria to produce high-energy molecules needed for cellular metabolism, and eventually for cell survival and growth. It can be thought of like having the batteries in your flashlight leak through the protective outer insulation, and the result is loss of your light as the batteries are drained rather quickly.

What does that mean in laymen’s terms to our bodies?

It means that damage is happening to your cells every day from contaminants, toxins and other sources. It’s primarily caused by oxidation, and it’s like rust formation. When metals rust, they oxidize and eventually fall apart. The human body can be thought of as similar. When our cells “rust,” our cellular membranes are damaged, and small holes appear in the membranes that allows ions that are normally sequestered in particular compartments to flow freely, damaging cellular function. That’s how we can end up in an energy-deficient state. The mitochondria are no longer protected by the “rusted” membranes, and they can no longer produce high energy molecules. This is perceived as chronic tiredness or fatigue that sleep won’t alleviate.

What exactly in the cell gets damaged from this oxidation?

During aging and most chronic diseases the production of free radical oxidative molecules, such as Reactive Oxygen and Nitrogen species (ROS/RNS), can cause oxidative stress and cellular damage, resulting in oxidation of lipids, proteins and our genetic material or DNA. When oxidized, these molecules are structurally and sometimes functionally changed. These ROS/RNS molecules target mitochondria primarily in the lipid parts of the mitochondrial membranes, as well as cellular and mitochondrial DNA.

Why is this important?

Everyone needs to understand that when our cell membranes are damaged, it hinders our ability to create high energy molecules, and this can open us up to disease. With the replacement of the damaged or oxidized lipids, it is possible to rebuild the cell membrane and actually reverse the damage. If we can rebuild cell function, we can rebuild an oxidation damaged body. From a diseased state, this offers hope and healing. From a healthy state, it offers longevity and it could hold off the effects of diseases associated with aging. The longer we can keep our cells healthy and producing energy, the longer we can live and enjoy active lives.

Is there something on the market now that can prevent this oxidative cell damage?

Dietary antioxidants and some accessory molecules, such as zinc, magnesium and certain vitamins, are important in maintaining antioxidant and freeradical scavenging systems that neutralize the damaging oxidants. In addition to zinc, magnesium and vitamins, there are at least 40 micronutrients required in the human diet, and aging increases their need to prevent age-associated damage to mitochondria and other cellular elements. Antioxidant use alone, however, may not be sufficient to maintain cellular components free of oxidative damage, and it cannot reverse the damage once it occurs. Thus, we have developed Lipid Replacement Therapy to replace oxidation-damaged membrane lipids.

What s Lipid Replacement Therapy?

Lipid Replacement Therapy is the dietary ingestion of undamaged lipids to replace damaged cellular and mitochondrial membrane phospholipids and other lipids.

However, just having undamaged lipids in your diet is not the same as Lipid Replacement Therapy, because dietary lipids can be oxidized before they even reach oour cells. The lipids have to be protected during storage, ingestion, digestion and transport to the cells. We have developed the product called NTFactor® to perform this function, and it has been shown to be very effective in reversing oxidative damage to critical membranes in animal and clinical lipid replacement studies.

What is NTFactor® and how does it work?

NTFactor® contains encapsulated or protected lipids taken as a daily oral supplement. The lipids are protected from oxidation and can be absorbed and transported into tissues without oxidative damage. This dietary supplement contains a variety of components, including phospholipids, glycophospholipids and other lipids, nutrients, probiotics (“friendly bacteria” that help our digestion), vitamins, minerals and plant extracts.

And this NTFactor® rebuilds my damaged cells?

Yes, it has been shown in several clinical trials to effectively rebuild mitochondrial membranes, improve their function and increase cellular energy, and most importantly, reduce overall fatigue.

In a study with severely chronic fatigued patients we found that fatigue was reduced approximately 40.5%, from severe to moderate or mild fatigue, after eight weeks of supplementation with NTFactor®.

In another recent study, moderately and mildly fatigued patients used NTFactor® for 8 or 12 weeks resulting in a 33% or 35.5% reduction in fatigue, respectively. In this clinical trial there was good correspondence between reductions in fatigue and gains in mitochondrial function. After only 8 weeks of NTFactor® , mitochondrial function was significantly improved and after 12 weeks supplementation, mitochondrial function was found to be similar to that of young healthy adults.

The latest NTFactor® research indicated that NTFactor® in special formulations can significantly reduce fatigue and increase energy in as little as a week. More will be

devoted to this in future issues.


So, Dr. Nicolson, do you recommend NTFactor®?

NTFactor® is the only ingredient I know on the market that effectively rebuilds mitochondrial functionby replacing damaged lipids in mitochondrial membranes, resulting in an increase in cellular energy and improved cellular function. I have personally conducted many studies on NTFactor® and have seen firsthand its effectiveness. I recommend it to everyone interested in reducing fatigue, increasing energy and improving health and longevity!

Learn More and Read the Clinical Trials Here at NTFactor.com