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NTFactor® Clinical Studies

Biochemist Assesses NTFactor®

Effects of Phosphoglycolipid Extract (NTFactor®) on Normal and Cancerous Cells

Author: NTFactor®/Tuesday, October 16, 2012/Categories: Clinical Trials

Cancerous Cells Of Tumors Import Phospholipids From Normal Cells

One of the fundamental biochemical differences between tumor cells and normal cells is the composition of the membrane lipid, including glycophospholipid and phospholipids. The phospholipid content of tumor cell membranes in known to be distinct from that of normal cells.

The difference in phospholipid content has been attributed to differences in rates of phospholipid transfer to the plasma membrane of aggressive tumors. There are two components to this difference in the ability of tumor membranes to acquire phospholipids from neighboring cells: first is a difference in phospholipids exchange due to phospholipids exchange protein (PLEP); second is a difference in phospholipids exchange rates due to the intrinsic lipid composition of the membrane. Over 90% of the Phosphatidylcholine in hepatoma microsomes can be exchanged within two hours at 37 degrees C. In Morris hepatoma cells, the transfer activity of phosphatidylcholine was 2 to 3 times higher thank in controls.However, only some of this difference  could be accounted for by an increase in PLEP activity, the rest being attributed to intrinsic differences in membrane lipids. Clearly, many types of tumors are able to incorporate extrinsic phospholipids into their membranes at the expense of normal cells of the body with the potential to deplete the phospholipids in the normal cells.

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