Restoring energy and vitality...Naturally

Search Clinical Trials

The Date On Your Supplement Is Not An Expiration Date!

Learn More

NTFactor® Clinical Studies

Fatigue Reduction in Chemotherapy

Nutrition Supplement NTFactor® Reduces Fatigue In Cancer Patients, Reduces Fatigue In Chemotherapy Patients.

Author: NTFactor®/Tuesday, October 16, 2012/Categories: Clinical Trials

Fatigue Reduction in Chemotherapy
Molecular Replacement in Cancer Therapy: Reversing Cancer Metabolic and Mitochondrial Dysfunction, Fatigue and the Adverse Effects of Cancer 

Kenneth A. Conklin and Garth L. Nicolson

Introduction: Cancers are associated with excess cellular oxidative stress, and during cancer treatment the addition of drug-induced oxidative stress can limit the effectiveness of therapy and cause a number of side effects, such as fatigue, nausea, vomiting and diarrhea, as well as more serious adverse effects, including cardiomyopathy, peripheral neuropathy, hepatotoxicity and pulmonary fibrosis.  

Review of the pertinent literature on oxidative stress during cancer cytotoxic therapy and the use of Molecular Replacement methods to reduce adverse effects by replacement of damaged cellular molecules. 

Most of the adverse effects of cancer therapy are due to oxidative stress-mediated damage to normal tissues.For example, loss of efficiency in the electron transport chain caused by membrane peroxidation and reduction in coenzyme Q10 can occur during cytotoxic therapy using anthracyclines, alkylating agents, platinum coordination complexes, epipodophyllotoxins and camptothecins. Molecular Replacement and antioxidant administration mitigates the damage to normal tissues and reduces the adverse effects of cancer therapy without loss of therapeutic effect. 

The acute and chronic adverse effects of cancer chemotherapy can be reduced by Molecular Replacement. Molecular Replacement of membrane lipids and enzymatic cofactors, such as coenzyme Q10, by administering nutritional supplements with antioxidants can prevent oxidative membrane damage and reductions of cofactors in normal tissues, respectively, restoring mitochondrial and other cellular functions and reducing chemotherapy adverse effects, such as cardiotoxicity, without significantly affecting therapeutic benefit. Recent clinical trials using cancer and non-cancer patients with chronic fatigue have shown the benefit of Molecular Replacement Therapy plus antioxidants in reducing the damage to mitochondrial membranes, restoring mitochondrial electron transport function, reducing fatigue and protecting cellular structures and enzymes from oxidative damage.

Number of views (3779)/Comments (0)

These statements have not been evaluated by the FDA. These products are not intended to diagnose, treat, cure or prevent any disease. The information provided on this site is for informational purposes only and is not intended as a substitute for advice from your physician or other health care professional or any information contained on or in any product label or packaging. You should not use the information on this site for diagnosis or treatment of any health problem or for prescription of any medication or other treatment. You should consult with a healthcare professional before starting any diet, exercise or supplementation program, before taking any medication, or if you have or suspect you might have a health problem. You should not stop taking any pharmaceutical product without first consulting your prescribing physician.






Nutritional Therapeutics' reputation is closely linked to the purity, balance, and integrity of our products. For nearly three decades, NTI develops, manufactures, and distributes both OEM, and proprietary formulations of nutrition supplements for healthcare professional, and consumer markets throughout the world. We produce only natural products with scientifically formulated food ingredients, avoiding additives found in other dietary supplements and pharmaceutical products.

Copyright 2013 NT Factor / Nutritional Therapeutics     Terms Of Use    Privacy Statement